The effect of therapeutic agents on biochemical and hematological blood parameters of dogs suffering from associated forms of mycoses

The chronic course of associated forms of mycoses involves the use of long courses of therapy, which have a proven toxic effect on the animal body. Therefore, a promising direction is the development and demonstration of the effectiveness of new treatment regimens. The article presents the results of studying the influence of therapeutic agents used in the proposed therapy regimens on biochemical and hematological blood parameters of dogs suffering from associated forms of mycoses. The material for the study was 46 dogs aged 2 to 9 years with a confirmed diagnosis of alternariosis and malassezia, and divided according to the principle of analogues into 3 experimental groups (19, 19, and 8 animals, respectively). Biochemical and hematological data were studied on automatic analyzers, which guaranteed the reliability of the results obtained. In the first two groups, blood parameters were within the reference values, and in the third group, animals had inflammatory processes in the liver (the benchmarks were increased biochemical indicators of ALT – 85.5 ± 5.84, AST – 48.0 ± 7.04, direct bilirubin – 5.5 ± 1.08 and total bilirubin – 9.5 ± 1.04). Each of the groups was given its own treatment regimen, which included the use of both etiotropic agents (Vetbio Dr.Pets shampoo, SkinGuard spray) and pathogenetic agents – Oclacitinib, Traumeel, Detoxol, and dietary feeding with Specific CDD-HY and Specific CKD feed. To control the course of the disease, blood parameters were monitored on the 10th day of therapy and after recovery. Animals were considered healthy if there were no clinical signs of the disease and with negative results of cultural and cytological studies. After the completion of the treatment course, the values of biochemical and hematological parameters were within the reference values in animals of all three groups. There were no significant differences in the levels of total blood protein and creatinine in the three experimental groups, both before and after the end of treatment. The effectiveness of a particular treatment regimen is evidenced, in particular, by the level of total bilirubin, which in all three groups was within the physiological norm after long-term therapy.