Development and Validation of Polygenic Risk Scores for Blood Pressure Traits in Continental African Populations
These findings highlight the importance of integrating diverse ancestries in PRS development and accounting for subpopulation genetic variation to improve the predictive accuracy of BP PRS in African populations.
Authors
- Yuji Zhang (ORCID: https://orcid.org/0000-0002-5429-6762)
- Clement Adebamowo (ORCID: https://orcid.org/0000-0002-6571-2880)
- Scott Hazelhurst (ORCID: https://orcid.org/0000-0002-0581-149X)
- Ananyo Choudhury (ORCID: https://orcid.org/0000-0001-8225-9531)
- Abram Bunya Kamiza (ORCID: https://orcid.org/0000-0002-3919-7651)
- Braxton D. Mitchell (ORCID: https://orcid.org/0000-0003-4920-4744)
- Ebuka Onyenobi
- Michael Zhong (ORCID: https://orcid.org/0000-0002-0769-8320)
- Sally N. Adebamowo (ORCID: https://orcid.org/0000-0003-4713-2433)
- Michèle Ramsay (ORCID: https://orcid.org/0000-0002-4156-4801)
- Palwendé Romuald Boua (ORCID: https://orcid.org/0000-0001-8325-2665)
- Jennifer S. Albrecht (ORCID: https://orcid.org/0000-0003-4838-2274)
- Opeyemi Soremekun (ORCID: https://orcid.org/0000-0002-7608-3848)
- Bamidele O. Tayo (ORCID: https://orcid.org/0000-0002-2277-3958)
- Tinashe Chikowore (ORCID: https://orcid.org/0000-0002-6743-751X)
- Segun Fatumo (ORCID: https://orcid.org/0000-0003-4525-3362)
- Timothy D. O’Connor (ORCID: https://orcid.org/0000-0002-0276-1896)
Institutions
- University of Maryland, Baltimore (US)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Queen Mary University of London (GB)
- Loyola University Chicago (US)
- University of the Witwatersrand (ZA)
- Anna Needs Neuroblastoma Answers (US)
- Farm Africa (GB)
- Institut de Recherche en Sciences de la Santé (BF)
- Uganda Virus Research Institute (UG)
Publication Details
- Journal
- Circulation Genomic and Precision Medicine
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1161/circgen.124.005048
- Citations
- 2
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 3.63