Development and Validation of Polygenic Risk Scores for Blood Pressure Traits in Continental African Populations

These findings highlight the importance of integrating diverse ancestries in PRS development and accounting for subpopulation genetic variation to improve the predictive accuracy of BP PRS in African populations.

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Publication Details

Journal
Circulation Genomic and Precision Medicine
Published
2025-05-27
DOI
https://doi.org/10.1161/circgen.124.005048
Citations
2
Primary Topic
Genetic Associations and Epidemiology
Type
article
Field-Weighted Citation Impact
3.63
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Development and Validation of Polygenic Risk Scores for Blood Pressure Traits in Continental African Populations

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Development and Validation of Polygenic Risk Scores for Blood Pressure Traits in Continental African Populations

Yuji Zhang, Clement Adebamowo, Scott Hazelhurst, Ananyo Choudhury, Abram Bunya Kamiza, Braxton D. Mitchell, Ebuka Onyenobi, Michael Zhong, Sally N. Adebamowo, Michèle Ramsay, Palwendé Romuald Boua, Jennifer S. Albrecht, Opeyemi Soremekun, Bamidele O. Tayo, Tinashe Chikowore, Segun Fatumo, Timothy D. O’Connor
article en
2 citations

Abstract

These findings highlight the importance of integrating diverse ancestries in PRS development and accounting for subpopulation genetic variation to improve the predictive accuracy of BP PRS in African populations.

Circulation Genomic and Precision MedicineVol. 18(3)
University of Maryland, Baltimore (US), Brigham and Women's Hospital (US), Harvard University (US), Queen Mary University of London (GB), Loyola University Chicago (US), University of the Witwatersrand (ZA), Anna Needs Neuroblastoma Answers (US), Farm Africa (GB), Institut de Recherche en Sciences de la Santé (BF), Uganda Virus Research Institute (UG)
Openalex Percentile: Top 8%
Genetic Associations and Epidemiology
3.63
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