Mesenchymal stem cell-derived exosome subpopulations remained consistent for 28 culture days, displaying therapeutic effects in a silicosis mouse model
This study proposes a holistic workflow for early-stage development of natural exosomes as therapeutics, offering guidance on industrial-scale production, purification, and characterization of exosomes with stable subpopulation distribution and functional consistency. It further addresses administration route selection in pulmonary disease animal models and heterogeneity assessment of natural exosomes. These advancements facilitate clinical translation of exosome-based therapies.
Authors
- Yongli Bao (ORCID: https://orcid.org/0000-0002-5972-1983)
- Qingjie Fan
- Lei Gao (ORCID: https://orcid.org/0000-0003-0377-2746)
- Xinhua Lei
- Yong‐Guang Yang (ORCID: https://orcid.org/0000-0003-4985-1247)
- Liguang Sun (ORCID: https://orcid.org/0000-0002-1662-7081)
- Yiding Bian
- Gang Hou (ORCID: https://orcid.org/0000-0002-5220-3761)
- Lina Zhang (ORCID: https://orcid.org/0000-0002-7747-7363)
- Xinyong Dong (ORCID: https://orcid.org/0000-0002-3445-5455)
- Wei Cheng (ORCID: https://orcid.org/0000-0001-5393-2926)
- Wenjia Wang (ORCID: https://orcid.org/0009-0000-6845-8809)
- Jianming Liu (ORCID: https://orcid.org/0000-0001-6527-6049)
- Mingming Deng
- Shaoliang Xing
- Jing Jin (ORCID: https://orcid.org/0009-0007-1691-8405)
Institutions
- Union Hospital (HK)
- Northeast Normal University (CN)
- Jilin University (CN)
- China-Japan Friendship Hospital (CN)
- Beijing VDJBio (China) (CN)
- First Hospital of Jilin University (CN)
- Beike Biotechnology (China) (CN)
- Jilin Electric Power Research Institute (China) (CN)
- Union Hospital (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-05-27
- DOI
- https://doi.org/10.3389/fcell.2025.1550447
- Citations
- 4
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- Department of Science and Technology of Jilin Province