Evaluation of frizzled class receptor 3 and miR-378 expression levels in cumulus cells of polycystic ovary syndrome women: A case-control study

High levels of <i>FZD3</i> and miR-378 in cumulus cells of immature oocytes can inhibit their maturation. <i>FZD3</i>, a component of the WNT signaling pathway, is overexpressed in immature oocytes and may negatively affect the maturation process. Additionally, miR-378 inhibits oocyte development by targeting and repressing essential genes. Currently, various aspects of microRNA function remain unknown. MiR-378 may exert its regulatory role by directly targeting the <i>FZD3</i> gene or by targeting other genes and mediators that interact with <i>FZD3</i> or the protein it encodes. This study may provide a foundation for further investigation of this hypothesis in future research.