Comprehensive Evaluation of the Antihyperlipidemic Effects of Sida cordifolia in Rodent Models

Hyperlipidemia is a major risk factor for cardiovascular diseases and metabolic disorders, necessitating the development of safe and effective therapeutic agents. Sida cordifolia, a medicinal plant traditionally used in Ayurvedic medicine, has shown potential lipid-lowering properties. This study aimed to comprehensively evaluate the antihyperlipidemic effects of Sida cordifolia extracts in rodent models. Wistar albino rats were divided into normal control, hyperlipidemic control, standard (atorvastatin-treated), and test groups treated with ethanolic and aqueous extracts of Sida cordifolia at varying doses. Hyperlipidemia was induced using a high-fat diet. Serum lipid profiles—including total cholesterol, triglycerides, LDL-C, and HDL-C—were measured at baseline and post-treatment. Histopathological analysis of liver tissues was also performed to assess hepatic integrity. Results indicated a significant reduction in total cholesterol, triglycerides, and LDL-C, with a concurrent increase in HDL-C levels in Sida cordifolia-treated groups, particularly at higher doses. Histological findings supported biochemical results, showing reduced lipid accumulation and improved hepatic architecture. These findings suggest that Sida cordifolia possesses potent antihyperlipidemic activity, supporting its potential use as a natural therapeutic agent for managing dyslipidemia. These findings position Sida cordifolia as a promising natural candidate for the management of hyperlipidemia, warranting further clinical validation and standardization for therapeutic use.