Design and Synthesis of Novel 5,6,7,8-Tetrahydropyrido[2,3-D]pyrimidine Derivatives as VCP/p97 Inhibitors for the Treatment of Acute Myeloid Leukemia (AML)
These results indicate that compound V12 is a potent p97 inhibitor with excellent in vitro and in vivo antitumor efficacy, which might provide a new therapeutic strategy for the treatment of AML.
Authors
- Hang Miao
- X. Ye (ORCID: https://orcid.org/0000-0001-8545-966X)
- Tiantian Wen (ORCID: https://orcid.org/0000-0003-0399-5202)
- Yongqiang Zhu (ORCID: https://orcid.org/0000-0003-0137-5907)
- Meng Lei (ORCID: https://orcid.org/0000-0003-2613-9417)
- Zebo Long
- Xueyuan Wang (ORCID: https://orcid.org/0000-0002-7400-5440)
Institutions
- Nanjing Forestry University (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-05-01
- DOI
- https://doi.org/10.2147/dddt.s509036
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00