Low dose radiotherapy combined with immune checkpoint inhibitors induces ferroptosis in lung cancer via the Nrf2/HO-1/GPX4 axis
This study demonstrated that LDR plus ICI induces ferroptosis through the Nrf2/HO-1/GPX4 pathway, resulting in a significant anti-tumor effect and providing a combinatorial strategy to overcome lung cancer. However, this combined strategy merits further clinical investigation.
Authors
- Yue‐Ping Xu (ORCID: https://orcid.org/0000-0002-3259-5593)
- Qiongjie Zhi
- Hui Zhu (ORCID: https://orcid.org/0000-0001-5539-1393)
- Guibing Ren (ORCID: https://orcid.org/0009-0000-3936-6649)
- Lujun Zhao (ORCID: https://orcid.org/0000-0001-5960-0201)
- Dongxia Li (ORCID: https://orcid.org/0000-0002-1344-022X)
- Jian Wang (ORCID: https://orcid.org/0000-0002-9286-2809)
- Ningbo Liu (ORCID: https://orcid.org/0000-0001-6166-2946)
- Jing Luo (ORCID: https://orcid.org/0009-0004-1576-473X)
Institutions
- Anhui Medical University (CN)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Chinese People's Armed Police Force Medical College Affiliated Hospital (CN)
- Hejian People's Hospital (CN)
- Chinese People's Armed Police General Hospital (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-27
- DOI
- https://doi.org/10.3389/fimmu.2025.1558814
- Citations
- 3
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Xinjiang