Saliva-derived extracellular vesicles: a promising therapeutic approach for salivary gland fibrosis
Our findings demonstrate that sEV exerts potent anti-fibrotic effects by modulating STAT3 signaling, offering a promising cell-free therapeutic strategy for SG fibrosis. These results highlight the potential of sEV as a natural nanotherapy for fibrotic SG disorders.
Authors
- Lili Wei (ORCID: https://orcid.org/0000-0001-7319-5900)
- Yong Cheng (ORCID: https://orcid.org/0000-0001-7434-8761)
- Lianhao Wang
- Xiaola Guo (ORCID: https://orcid.org/0000-0001-5594-8905)
- Boyuan Peng (ORCID: https://orcid.org/0009-0002-9226-6406)
- Bo Li (ORCID: https://orcid.org/0000-0003-2928-1531)
- Guangli Han (ORCID: https://orcid.org/0000-0003-4723-2266)
- Jialing Kang
- Shijiao Pan
Institutions
- Wuhan University (CN)
- Stomatology Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1186/s12967-025-06620-1
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province