Evaluation of the Efficacy of Integrated Traditional Chinese and Western Medicine in the Treatment of Cholestatic Liver Disease

目的：探讨中西医结合治疗胆汁淤积性肝病的临床疗效及安全性，为优化治疗方案提供依据。方法：纳入96例胆汁淤积性肝病患者，随机分为实验组(48例)和对照组(48例)。实验组采用茵陈蒿汤合四逆散、四妙散加减联合多烯磷脂酰胆碱与异甘草酸镁治疗；对照组采用丁二磺酸腺苷蛋氨酸联合相同西药治疗。两组均连续治疗4周，每周监测肝功能指标(总胆红素、ALP、GGT)，评估疗效及不良反应。结果：治疗4周后，实验组总有效率为71.0% (31/44)，显著高于对照组的57.0% (24/42) (P 0.05)。结论：中西医结合治疗胆汁淤积性肝病可显著改善肝功能指标，疗效优于单纯西医治疗，且安全性良好，值得临床推广。未来需进一步细化病因分层研究，以提升治疗精准性。 Objective: To investigate the clinical efficacy and safety of integrated traditional Chinese and Western medicine in the treatment of cholestatic liver disease, and to provide a basis for optimizing treatment regimens. Methods: 98 patients with cholestatic liver disease were enrolled and randomly divided into an experimental group (48 cases) and a control group (50 cases). The experimental group received modified Yinchenhao Decoction combined with Sini Powder and Simiao Powder, as well as polyene phosphatidylcholine and magnesium isoglycyrrhizinate. The control group received adenosylmethionine combined with the same Western medicines. Both groups were treated for 4 weeks, with weekly monitoring of liver function indicators (total bilirubin, ALP, GGT) to evaluate efficacy and adverse reactions. Results: After 4 weeks of treatment, the total effective rate in the experimental group was 71.0% (31/44), significantly higher than 57.0% (24/42) in the control group (P 0.05). Conclusion: Integrated traditional Chinese and Western medicine therapy can significantly improve liver function indicators in cholestatic liver disease, with superior efficacy and good safety compared to Western medicine alone, making it worthy of clinical promotion. Future studies should refine etiological stratification to enhance treatment precision.