Identification of Yunnan Guangnan <i>Dendrobium officinale</i> With Different Growth Years Using UHPLC–Orbitrap–MS

ABSTRACT Dendrobium officinale from Guangnan was screened nontargeted using UHPLC–Orbitrap‐MS for different growth years. OPLS‐DA effectively differentiated D. officinale based on growth years, identifying 70 different compounds. Eight indole diketopiperazine alkaloids did not differ considerably among the growth years. The differential compounds of D. officinale with 4 years of growth were more distinct from other years, with 10 compounds showing greater variability. Pathways in cancer, cancer metabolic pathways, metabolic pathways, chemical carcinogenesis—receptor activation were more enriched. This suggests that D. officinale functional compounds have pharmacological activities in these areas and can regulate the metabolic processes of lipids and atherosclerosis.