Expression and Clinical Significance of IL-33 and IL-25 in Post-Irradiation Otitis Media with Effusion
IL-33 and IL-25 synergistically drive ILC2-mediated chronic inflammation in radiation-induced OME, with IL-25 emerging as a biomarker for radiotherapy-associated Eustachian tube dysfunction. The 6-month cytokine surge post-radiation highlights a therapeutic window for targeted interventions to mitigate long-term complications.
Authors
- Jiaying Pan
- Zhihe Lin (ORCID: https://orcid.org/0009-0004-0428-4095)
- Shaoyan Feng (ORCID: https://orcid.org/0000-0002-2894-3647)
- Lei Chen (ORCID: https://orcid.org/0000-0002-0282-1174)
- Zhaoxia Zhang (ORCID: https://orcid.org/0000-0002-0778-3234)
- Zibin Liang (ORCID: https://orcid.org/0000-0001-5866-5169)
- Dan Ohtan Wang (ORCID: https://orcid.org/0000-0003-0477-6431)
- Chuntao Deng (ORCID: https://orcid.org/0009-0002-0049-8497)
- Minting Chen (ORCID: https://orcid.org/0009-0004-7345-6970)
- Jinlian Li (ORCID: https://orcid.org/0009-0005-9163-5216)
- Bo Lyu (ORCID: https://orcid.org/0009-0004-8493-2039)
Institutions
- Sun Yat-sen University (CN)
- Eye & ENT Hospital of Fudan University (CN)
- Fifth Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-05-01
- DOI
- https://doi.org/10.2147/jir.s507516
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Sun Yat-sen University
- Natural Science Foundation of Guangdong Province
- Fundamental Research Funds for the Central Universities