EURYALE FEROX SALISB. AMELIORATES CADMIUM-INDUCED TESTICULAR AND HEPATIC IMPAIRMENTS IN MALE MOUSE MODEL

In humans, cadmium exhibits a potent compounding effect and is one of the major concerns, which can lead to several dangerous health hazards, including hostile reproductive health. There are several synthetic medications available to reduce its toxicity, but with a wide range of adverse effects. This scenario necessitates the pursuit of natural compound-based medicinal formulations. Therefore, the aim of the present study was to investigate the role of Makhana, Euryale ferox Salisb., against cadmium-induced testicular and hepatic pathophysiology, oxidative stress, hormone levels, and other parameters of testis and liver damage. In mice, its extract was administered orally on a daily basis for 21 days, and they were also subjected to Cadmium chloride solution using oral gavage. The animals were subjected to physical, biochemical, and histological analysis after the completion of dosage. Results indicated that Makhana extract has a significant therapeutic role in overcoming cadmium toxicity. The makhana ameliorates haematological indices, testis weight, hormonal levels, and histopathological alterations in a significant way. The makhana extract ameliorates cadmium-induced testicular and hepatic impairments, modulating testicular and hepatic histoarchitecture, steroid hormone, and oxidative stress. Thus, it can be suggested that foxnuts can be a potential candidate for treating cadmium toxicity.