Associated Mechanisms and Interventions for Osteosarcopenia

肌少症、骨质疏松是两种常见的老年退行性疾病，随着全球人口老龄化加剧，这两种疾病的发病率不断上升，严重影响老年人的生活质量。近年来研究发现，骨质疏松与肌少症在发病机制上存在密切联系，若二者同时存在则被称为“骨肌减少症”(osteosarcopenia)，对于患上骨肌减少症的老年人来说，跌倒、骨折、住院及死亡率会大大地增高。本文将从发病机制和干预治疗等方面综述骨质疏松与肌少症的最新研究进展。Sarcopenia and osteoporosis are two prevalent age-related degenerative disorders. With the accelerating global aging population, the incidence of these conditions continues to rise, significantly impairing the quality of life in older adults. Recent studies have revealed a close pathophysiological link between osteoporosis and sarcopenia. The co-occurrence of both conditions is termed “osteosarcopenia”, which markedly increases the risks of falls, fractures, hospitalization, and mortality in affected elderly individuals. This article reviews the latest research advances in osteosarcopenia, with a focus on its underlying mechanisms and therapeutic interventions.