The Research Progress on Notch1 in the Development of Malignant Tumors

Notch1属于Notch信号通路的重要蛋白受体，是一种配体激活的转录因子。Notch1作为一种转录因子，通过调控细胞增殖、迁移、侵袭、上皮–间充质转化、肿瘤干细胞特性、免疫逃逸等细胞活动参与多种恶性肿瘤的进展。本文就Notch1在常见恶性肿瘤发展中的相关研究进展进行综述，旨在为肿瘤的诊疗提供新的思路。Notch1 is an important receptor protein in the Notch signaling pathway and a ligand-activated transcription factor. As a transcription factor, Notch1 participates in the progression of various malignant tumors by regulating cellular activities such as cell proliferation, migration, invasion, epithelial-mesenchymal transition, tumor stem cell characteristics, and immune evasion. This review summarizes the research progress of Notch1 in the development of common malignant tumors, aiming to provide new insights for tumor diagnosis and therapy.