Upregulation of SIRT1 ameliorates apoptosis of rat nucleus pulposus cells under oxidative stress through FoxO1/β-catenin pathway
These results suggest that activation of the SIRT1/FoxO1/β-catenin axis can diminish ageing-related phenotypes and cell apoptosis in NPCs, inhibiting the oxidative stress-induced ageing process triggered by H₂O₂. These findings may offer a new perspective for the treatment of intervertebral disc degeneration (IDD) in the future.
Authors
- Weisheng Hong (ORCID: https://orcid.org/0009-0009-0185-3164)
- Haijun Teng (ORCID: https://orcid.org/0000-0002-0496-4013)
- Sheng Wang (ORCID: https://orcid.org/0000-0002-5625-403X)
- Sishun Zhao (ORCID: https://orcid.org/0009-0002-4812-1815)
- Hongtao Hu (ORCID: https://orcid.org/0000-0003-3704-6646)
Institutions
- Weifang Medical University (CN)
Publication Details
- Journal
- Folia Histochemica et Cytobiologica
- Published
- 2025-05-27
- DOI
- https://doi.org/10.5603/fhc.104395
- Citations
- 2
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 2.45