Application Effect of Linaclotide Combined with Polyethylene Glycol Dissolved in 1l Pulse Beverage in Bowel Preparation for Colonoscopy

Colorectal cancer is a global health threat, and colonoscopy is crucial for early diagnosis. Traditional 2L or 3L polyethylene glycol (PEG) for bowel preparation has issues with patient tolerance. This randomized, endoscopist - blinded, single - center study compared 1L PEG + 580μg linaclotide (1L PEG + L group) and 2L PEG alone in 993 patients scheduled for colonoscopy. There were no significant differences in Boston Bowel Preparation Scale (BBPS) scores, polyp detection rate, or adenoma detection rate between the two groups (P>0.05). However, the incidence of adverse events was 8.87% in the 1L PEG + L group and 33.88% in the 2L PEG group (P