Platelet-rich fibrin-conditioned medium promotes osteogenesis of dental pulp stem cells through TGF-β and PDGF signaling
PRF-CM activates TGF-β and PDGF signaling pathways, thereby promoting the osteogenic differentiation of DPSCs. Moreover, the volume of PRF-CM obtained was approximately three times greater than the blood sample volume. These findings suggest that PRF-CM could serve as an effective alternative to HAS or FBS for bone regeneration therapy using MSCs.
Authors
- Yasuyuki Fujii (ORCID: https://orcid.org/0000-0003-1567-1408)
- Yoko Kawase‐Koga (ORCID: https://orcid.org/0000-0003-4746-7102)
- Ayano Hatori (ORCID: https://orcid.org/0009-0001-1719-8469)
- Mikiko Ikehata
- Daichi Chikazu (ORCID: https://orcid.org/0000-0003-0114-3647)
- Shahram Ghanaati (ORCID: https://orcid.org/0000-0002-7897-0854)
- Takashi Yoshida
- Ayaka Sato
Institutions
- Goethe University Frankfurt (DE)
- Tokyo Medical University (JP)
- Tokyo Women's Medical University (JP)
Publication Details
- Journal
- Regenerative Therapy
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1016/j.reth.2025.05.006
- Citations
- 5
- Primary Topic
- Periodontal Regeneration and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 9.18
Funders
- Japan Society for the Promotion of Science