Combined resistance mechanisms leading to high-level of cefiderocol resistance among NDM-like producing E. coli ST167 clinical isolates
We identified a variety of NDM-producing E. coli isolates exhibiting high level of resistance to FDC as a result of the combined effect of CirA deficiency, along with production of NDM-type enzymes. The spread of such resistance phenotype across Europe poses great concern on the clinical efficacy of this novel drug. Additionally, the identification of an FDC- and AZA-resistant NDM-5 producing E. coli isolate represents one of the ultimate evolutions with a possible step towards pan-resistance.
Authors
- Juan Bosch Duran
- Mustafa Sadek (ORCID: https://orcid.org/0000-0003-3983-3862)
- Trinad Chakraborty (ORCID: https://orcid.org/0000-0002-1452-4759)
- Laurent Poirel (ORCID: https://orcid.org/0000-0001-5160-5286)
Institutions
- University of Fribourg (CH)
- South Valley University (EG)
- Justus-Liebig-Universität Gießen (DE)
- Al-Mustafa International University (IR)
- German Center for Infection Research (DE)
Publication Details
- Journal
- European Journal of Clinical Microbiology & Infectious Diseases
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1007/s10096-025-05166-w
- Citations
- 4
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 2.36
Funders
- Université de Fribourg