Luteolin mitigates oxidative stress and multi-organ impairment in a propionic acid-induced rodent model of autism
Luteolin effectively alleviated oxidative stress, restored antioxidant defenses, and enhanced liver, kidney, and intestinal barrier functions in a PPA-induced ASD model. These findings underscored its therapeutic potential as a natural intervention for ASD-related systemic dysfunctions. Further clinical studies are needed to evaluate its translational applicability in ASD management.
Authors
- Arwa Ishaq A. Khayyat (ORCID: https://orcid.org/0000-0003-3376-7008)
- Mona Alonazi (ORCID: https://orcid.org/0000-0002-9430-7980)
- Altaf Alabdali
- Abir Ben Bacha (ORCID: https://orcid.org/0000-0001-6372-7483)
- Eman Alshehri (ORCID: https://orcid.org/0000-0003-2541-0236)
- Areej Ali Alzahrani
Institutions
- King Saud University (SA)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-05-27
- DOI
- https://doi.org/10.3389/fnut.2025.1583119
- Citations
- 6
- Primary Topic
- Autism Spectrum Disorder Research
- Type
- article
- Field-Weighted Citation Impact
- 8.59
Funders
- King Saud University