Tryptophan metabolites exert potential therapeutic activity in graves’ orbitopathy by ameliorating orbital fibroblasts inflammation and proliferation
Trp metabolites IAA maybe a novel biomarker for GO progression. And IPA, ILA and IAA may play a protective role in GO by regulating inflammation and proliferation in orbital fibroblasts, suggesting their potential as therapeutic targets for GO treatment.
Authors
- Jiaqi Lin
- Rongrong Xie (ORCID: https://orcid.org/0000-0003-0305-4752)
- Xin Zhong (ORCID: https://orcid.org/0000-0002-6840-1922)
- Tingting Shi (ORCID: https://orcid.org/0000-0002-7008-9229)
- Xi Cao (ORCID: https://orcid.org/0000-0002-9650-3897)
- Zhijia Hou
- Xinyu Xu (ORCID: https://orcid.org/0000-0001-7328-5156)
- Weili Yang (ORCID: https://orcid.org/0000-0003-3646-7772)
Institutions
- Beijing Tongren Hospital (CN)
- Capital Medical University (CN)
Publication Details
- Journal
- Journal of Endocrinological Investigation
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1007/s40618-025-02593-6
- Citations
- 2
- Primary Topic
- Ophthalmology and Eye Disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Beijing Municipality