H3K18 lactylation-mediated Ythdf2 activation restrains mouse female germline stem cell proliferation via promoting Ets1 mRNA degradation
Overall, our study reveals that YTHDF2 intrinsically restrains mouse FGSC proliferation and provides a potential strategy to increase FGSC abundance for its potential clinical application.
Authors
- Bo Xu (ORCID: https://orcid.org/0000-0001-8693-3060)
- Yunqiang Wu
- Yonglin Peng (ORCID: https://orcid.org/0000-0003-3446-3030)
- Xiaodong Zhao (ORCID: https://orcid.org/0000-0002-8344-9852)
- Kang Zou (ORCID: https://orcid.org/0000-0002-1253-1816)
- Ji Wu (ORCID: https://orcid.org/0000-0002-6424-9783)
- Ruiqi Liu (ORCID: https://orcid.org/0009-0003-9113-7327)
- Shu Zhang (ORCID: https://orcid.org/0009-0002-0774-0047)
- Wenfei Du (ORCID: https://orcid.org/0000-0003-3526-5730)
- Sang Lin
Institutions
- Nanjing Agricultural University (CN)
- Shanghai Jiao Tong University (CN)
- Ministry of Education (KR)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1186/s13148-025-01890-4
- Citations
- 3
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Key Research and Development Program of China