Expert Consensus on the Diagnosis and Treatment of Malignant Pericardial Mesothelioma
ABSTRACT Primary malignant pericardial mesothelioma (PMPM), a rare pericardium‐derived malignancy, urgently requires standardized diagnostic and therapeutic protocols. This consensus, established by the Chinese Alliance of Research for Mesothelioma (ChARM) through the integration of evidence‐based research and multicenter clinical expertise, addresses the following critical aspects: The disease is characterized by insidious progression and local invasiveness with the majority of cases diagnosed at advanced stages. Current multimodal therapeutic strategies include radical surgery, platinum‐based combination chemotherapy, and precision radiotherapy. The introduction of PD‐1/PD‐L1 inhibitors has extended median survival to up to 24 months. The consensus emphasizes the diagnostic utility of multimodal imaging combined with histopathological immunohistochemical analysis. Furthermore, a stratified prognostic model incorporating tumor biomarkers is proposed to standardize follow‐up surveillance protocols, ensuring a systematic monitoring of disease progression and therapeutic efficacy.
Authors
- Zhengfei Zhu (ORCID: https://orcid.org/0000-0001-7537-3619)
- Gen Lin (ORCID: https://orcid.org/0000-0001-9411-5519)
- Jinpu Yu (ORCID: https://orcid.org/0000-0002-5982-2266)
- Yuanzhi Lü
- Xinqing Lin (ORCID: https://orcid.org/0000-0001-9436-2229)
- Xiuyu Cai (ORCID: https://orcid.org/0000-0002-5251-9272)
- Jing Cai (ORCID: https://orcid.org/0000-0002-6792-4959)
- Weiwei Pan (ORCID: https://orcid.org/0000-0002-3574-3758)
- Yina Wang (ORCID: https://orcid.org/0000-0002-2326-2754)
- You‐cai Zhu (ORCID: https://orcid.org/0009-0002-5912-633X)
- Huaiqing Xiao
- Shi Lin (ORCID: https://orcid.org/0000-0003-2698-301X)
- Guansong Wang (ORCID: https://orcid.org/0000-0002-5184-0777)
- Zhefeng Liu
- Chengzhi Zhou (ORCID: https://orcid.org/0000-0003-0029-6879)
- Bing Wan (ORCID: https://orcid.org/0000-0002-8370-2977)
- Jianfei Fu (ORCID: https://orcid.org/0000-0002-3036-1056)
- Yinbin Zhang (ORCID: https://orcid.org/0000-0002-1105-8131)
- Enyong Dai (ORCID: https://orcid.org/0000-0002-5263-3454)
- Xuefei Shi (ORCID: https://orcid.org/0000-0002-8065-1887)
- Zhiying Shao (ORCID: https://orcid.org/0000-0001-5944-0439)
- Yi Shen (ORCID: https://orcid.org/0000-0002-4447-1053)
- Tangfeng Lv (ORCID: https://orcid.org/0000-0001-7224-8468)
- Chuanhao Tang (ORCID: https://orcid.org/0000-0002-4219-3790)
- Fan Wu (ORCID: https://orcid.org/0000-0002-0495-6814)
- Bihui Li (ORCID: https://orcid.org/0000-0003-0993-6537)
- Xiao‐Dong Jiao (ORCID: https://orcid.org/0000-0002-9663-8548)
- Yong Fang (ORCID: https://orcid.org/0000-0003-1910-6465)
- Binbin Song (ORCID: https://orcid.org/0000-0002-7093-0401)
- Xiaobing Chen (ORCID: https://orcid.org/0000-0002-6831-1417)
- Xingxiang Pu (ORCID: https://orcid.org/0000-0002-2743-7080)
- Yue Hao (ORCID: https://orcid.org/0000-0002-4725-6084)
- Fei Pang (ORCID: https://orcid.org/0000-0003-3494-2381)
- Yingshui Yao (ORCID: https://orcid.org/0000-0002-6690-4585)
- Dongqing Lv (ORCID: https://orcid.org/0000-0001-8226-9596)
- Mingxiang Ye
- Zhengbo Song (ORCID: https://orcid.org/0000-0002-4817-7775)
- Jiandong Wang (ORCID: https://orcid.org/0000-0002-8560-3884)
- Jian Feng (ORCID: https://orcid.org/0000-0003-3411-827X)
- Liyun Miao (ORCID: https://orcid.org/0000-0001-9586-3244)
- Nong Yang (ORCID: https://orcid.org/0000-0003-0997-3645)
- Zhansheng Jiang
- Wen‐Zhao Zhong (ORCID: https://orcid.org/0000-0002-8917-8635)
- Donglai Lv
- Chuangzhou Rao (ORCID: https://orcid.org/0000-0003-1101-5120)
- Xiaomin Niu (ORCID: https://orcid.org/0000-0003-1079-1785)
- Kainan Li (ORCID: https://orcid.org/0000-0002-1353-1332)
- Rui Meng (ORCID: https://orcid.org/0000-0002-6463-9255)
- Hongmei Zhang (ORCID: https://orcid.org/0000-0002-6181-7300)
- Wenfeng Li (ORCID: https://orcid.org/0000-0001-7213-8648)
- Xiaofeng Chen (ORCID: https://orcid.org/0000-0002-0457-6854)
- Ke Wang (ORCID: https://orcid.org/0000-0003-3812-7018)
- Hong Wang (ORCID: https://orcid.org/0000-0001-8098-4473)
- Dong Wang (ORCID: https://orcid.org/0000-0001-7877-7440)
- Jian Zhang (ORCID: https://orcid.org/0000-0002-8243-3031)
- Zhen Wang (ORCID: https://orcid.org/0000-0002-4456-8752)
- Feng Wang (ORCID: https://orcid.org/0000-0003-1089-3095)
- Yu Zhang (ORCID: https://orcid.org/0000-0002-4594-3868)
- Xuewen Liu (ORCID: https://orcid.org/0000-0003-1947-1542)
- Jingjing Liu (ORCID: https://orcid.org/0000-0001-8333-5233)
- Zhang Zhang (ORCID: https://orcid.org/0000-0001-6603-5060)
- Hongbing Liu (ORCID: https://orcid.org/0000-0001-7718-3288)
- Wenxian Wang (ORCID: https://orcid.org/0000-0002-3047-4149)
- Yong Song (ORCID: https://orcid.org/0000-0003-2391-5820)
- Aijun Liu (ORCID: https://orcid.org/0000-0001-7103-138X)
- Hui Guo (ORCID: https://orcid.org/0000-0001-9780-0845)
- Junping Zhang (ORCID: https://orcid.org/0000-0002-7271-8615)
- Yuan Li (ORCID: https://orcid.org/0000-0001-5651-819X)
- Zongyang Yu (ORCID: https://orcid.org/0000-0002-2964-3881)
- Jin Zhou (ORCID: https://orcid.org/0000-0003-1106-6200)
- Jisheng Li (ORCID: https://orcid.org/0000-0002-4186-6228)
- Zhongwu Li (ORCID: https://orcid.org/0000-0003-3440-9077)
- Yiping Zhang (ORCID: https://orcid.org/0000-0002-0132-7959)
- Zhaofeng Wang (ORCID: https://orcid.org/0000-0003-3641-7011)
- Jianhui Huang
- Lin Wu
- Miao Li (ORCID: https://orcid.org/0000-0002-5836-3619)
- J. Jin (ORCID: https://orcid.org/0000-0002-9903-9276)
- Yongchang Zhang (ORCID: https://orcid.org/0000-0002-6829-7176)
- Long Huang (ORCID: https://orcid.org/0000-0003-4925-5162)
- Shirong Zhang (ORCID: https://orcid.org/0000-0001-9334-1637)
- Ziming Li (ORCID: https://orcid.org/0009-0004-7529-7176)
- Wenfeng Fang (ORCID: https://orcid.org/0000-0002-6440-8246)
- Ping Zhan (ORCID: https://orcid.org/0000-0002-7983-976X)
- Jingping Yuan (ORCID: https://orcid.org/0000-0002-2922-4839)
- Anwen Liu (ORCID: https://orcid.org/0000-0003-4012-9717)
- Xixu Zhu (ORCID: https://orcid.org/0000-0003-4027-8819)
- Yingying Du (ORCID: https://orcid.org/0000-0002-5149-4632)
- Yu Chen
- Yingshi Piao (ORCID: https://orcid.org/0000-0002-7466-1595)
- Shengjie Yang (ORCID: https://orcid.org/0000-0002-2403-7911)
- Qing Ji (ORCID: https://orcid.org/0000-0002-2967-5445)
- Qian Chu (ORCID: https://orcid.org/0000-0001-8192-7630)
- Zhenying Guo
- Jingxun Wu
- Yu Yao
- Liping Wang (ORCID: https://orcid.org/0000-0002-9821-4802)
- Meiyu Fang
- Xuelei Ma
- Yinghua Ji (ORCID: https://orcid.org/0009-0006-3532-7582)
- Xiaoyan Li (ORCID: https://orcid.org/0000-0002-8807-4199)
- Qian Wang (ORCID: https://orcid.org/0000-0003-4940-1123)
- Lingfeng Min
- Huijing Feng
- Pingli Sun (ORCID: https://orcid.org/0000-0002-7511-3080)
- Dongmei Yuan
- Yue Feng
- C. Xu (ORCID: https://orcid.org/0000-0002-9021-6731)
- Zhijie Wang (ORCID: https://orcid.org/0009-0009-8175-2426)
- Xianbin Liang
- Shenglin Ma
- Lin Wang (ORCID: https://orcid.org/0000-0002-1588-588X)
- Ling Xu (ORCID: https://orcid.org/0000-0002-5097-8256)
Institutions
- Beijing Tongren Hospital (CN)
- Fujian Medical University (CN)
- Nanjing University of Chinese Medicine (CN)
- Union Hospital (HK)
- Central South University (CN)
- Nanchang University (CN)
- Army Medical University (CN)
- Shandong University (CN)
- Sun Yat-sen University (CN)
- Jinan University (CN)
- Guilin Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Capital Medical University (CN)
- Jilin University (CN)
- Anhui Medical University (CN)
- Chinese Academy of Sciences (CN)
- Nantong University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Sichuan University (CN)
- Fudan University (CN)
- National Health and Family Planning Commission (CN)
- Wenzhou Medical University (CN)
- Nanjing General Hospital of Nanjing Military Command (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Sir Run Run Shaw Hospital (CN)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Shanghai Chest Hospital (CN)
- Chinese PLA General Hospital (CN)
- Huzhou Normal University (CN)
- Wuhan University (CN)
- Zhengzhou University (CN)
- Affiliated Hospital of Nantong University (CN)
- First Affiliated Hospital of Xiamen University (CN)
- Beijing Tian Tan Hospital (CN)
- Jiaxing University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Peking University Cancer Hospital (CN)
- Qinghai No.3 People's Hospital (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Jilin Province Tumor Hospital (CN)
- Zhejiang Cancer Hospital (CN)
- Shanghai Changzheng Hospital (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- Nanjing Drum Tower Hospital (CN)
- Lishui Central Hospital (CN)
- First Affiliated Hospital of Xinxiang Medical University (CN)
- Hunan Cancer Hospital (CN)
- Xinqiao Hospital (CN)
- Sichuan Cancer Hospital (CN)
- Fuzhou General Hospital of Nanjing Military Command (CN)
- Zhujiang Hospital (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Zhongshan Hospital (CN)
- Wuhan Union Hospital (CN)
- Zhejiang Provincial People's Hospital (CN)
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
- Peking University International Hospital (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- First Hospital of Jiaxing (CN)
- Renmin Hospital of Wuhan University (CN)
- Second Affiliated Hospital of Jilin University (CN)
- Henan Cancer Hospital (CN)
- Guangdong Academy of Medical Sciences (CN)
- Sun Yat-sen University Cancer Center (CN)
- Fujian Provincial Cancer Hospital (CN)
- Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN)
- Zhengzhou People's Hospital (CN)
- Jiangsu Province Hospital (CN)
- Guangdong Provincial People's Hospital (CN)
- Guizhou Provincial People's Hospital (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Nanjing Jiangning Hospital (CN)
- Third Xiangya Hospital (CN)
- Shanxi Academy of Medical Sciences (CN)
- Xijing Hospital (CN)
- Tongji Hospital (CN)
- Qilu Hospital of Shandong University (CN)
- Xi'an Chest Hospital (CN)
- First Affiliated Hospital of Jinan University (CN)
- University of Chinese Academy of Sciences (CN)
- Hangzhou Medical College (CN)
- Hangzhou Cancer Hospital (CN)
- First Affiliated Hospital Zhejiang University (CN)
- State Key Laboratory of Biotherapy
- State Key Laboratory of Oncology in South China
- Huazhong University of Science and Technology (CN)
- Southern Medical University (CN)
- Zhejiang University (CN)
- Yangzhou University (CN)
- Nanjing Medical University (CN)
- Nanjing University (CN)
- Guangzhou Medical University (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Med Research
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1002/mdr2.70003
- Citations
- 1
- Primary Topic
- Occupational and environmental lung diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- China Primary Health Care Foundation
- National Health Commission of the People's Republic of China
- Natural Science Foundation of Zhejiang Province