Metabolic‐Immune Suppression Mediated by the SIRT1‐CX3CL1 Axis Induces Functional Enhancement of Regulatory T Cells in Colorectal Carcinoma (Adv. Sci. 17/2025)
Colorectal Carcinoma This study reveals that SIRT1, a metabolic regulator in colorectal cancer (CRC), enhances immunosuppression by upregulating CX3CL1 to drive TCF7(+) regulatory T cell (TCF7(+)Treg) differentiation into potent TNFRSF9(+) subsets. The cover art depicts T cells as robotic sentinels battling CRC cells, where SIRT1‐driven CX3CL1 forms defensive barriers, countered by combination therapies targeting CX3CR1 and PD‐1. More details can be found in article number 2404734 by Houjie Liang, Jianjun Li, Zhihao Wei, Yan Dong, and co‐workers. [Image: see text]
Authors
- Limei Liu
- Ruiyang Zi (ORCID: https://orcid.org/0009-0003-0139-2376)
- Jianjun Li (ORCID: https://orcid.org/0000-0003-4402-5472)
- Fanghao Lu
- Zhihao Wei (ORCID: https://orcid.org/0009-0008-4174-9241)
- Zhiheng Bian
- Taorui Liu
- Xuesong Wang (ORCID: https://orcid.org/0000-0003-3259-1880)
- Fan Zhang (ORCID: https://orcid.org/0000-0002-0786-9687)
- Han Peng (ORCID: https://orcid.org/0000-0003-0393-4098)
- Yan Dong (ORCID: https://orcid.org/0000-0002-4018-3839)
- Rui Zhang (ORCID: https://orcid.org/0000-0003-0981-1021)
- Qing Qin
- Yijie Wang (ORCID: https://orcid.org/0009-0008-5131-9122)
- Houjie Liang (ORCID: https://orcid.org/0000-0002-5924-7783)
- Haoran Jiang (ORCID: https://orcid.org/0009-0006-9575-3575)
- Yixin Sun
- Xiang Zhao (ORCID: https://orcid.org/0009-0009-3260-7986)
- Chao Zhang (ORCID: https://orcid.org/0000-0003-3867-6455)
Publication Details
- Journal
- Advanced Science
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1002/advs.202570121
- Primary Topic
- Chemokine receptors and signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00