Transcriptomic Profiling Unveils <i>EDN3</i> <sup>+</sup> Meningeal Fibroblasts as Key Players in Sturge‐Weber Syndrome Pathogenesis (Adv. Sci. 17/2025)
SyndromeMeningeal fibroblasts contribute to the progression of leptomeningeal vascular malformation in Sturge-Weber syndrome (SWS).In article number 2408888, Guoming Luan, Woo-ping Ge, Yuguang Guan, and colleagues identify an EDN3 + meningeal fibroblast cluster, highlighting WNT5A as a potential key driver of SWS progression and a promising therapeutic target.
Authors
- Daosheng Ai
- Guoming Luan (ORCID: https://orcid.org/0000-0001-5084-2458)
- Zizhang Cheng (ORCID: https://orcid.org/0000-0002-6560-0280)
- Fengzhi Li (ORCID: https://orcid.org/0000-0002-2299-7951)
- Woo‐Ping Ge (ORCID: https://orcid.org/0000-0001-8219-1055)
- Jinyi Zuo
- Shu Wang (ORCID: https://orcid.org/0000-0002-5914-0804)
- Yuguang Guan (ORCID: https://orcid.org/0000-0001-9945-2872)
- Zhanying Bi
- Mingguo Xie (ORCID: https://orcid.org/0000-0002-5100-2773)
- Xiaoli Li (ORCID: https://orcid.org/0000-0003-1359-5130)
- Xiongfei Wang
- Sun Wei-jin
- Xueling Qi (ORCID: https://orcid.org/0000-0002-8483-8382)
- Tang Ming
Publication Details
- Journal
- Advanced Science
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1002/advs.202570125
- Primary Topic
- Vascular Malformations and Hemangiomas
- Type
- article
- Field-Weighted Citation Impact
- 0.00