Nationwide Study on Factor V Deficiency in China: Clinical Characteristics, Genotype, and Treatment Approaches
This study characterizes China's largest FV-deficient cohort, identifying 13 novel F5 variants. Light chain variants predicted severe coagulation disorder, while on-demand FFP achieved effective haemostasis. High prevalences of menorrhagia (38.9%) and ovarian cysts (22.2%) in reproductive-age females highlight urgent needs for gender-specific interventions and management of this rare disorder.
Authors
- Renchi Yang (ORCID: https://orcid.org/0000-0003-3741-8518)
- Feng Xue (ORCID: https://orcid.org/0000-0002-5947-3924)
- Lingling Chen (ORCID: https://orcid.org/0000-0002-6224-7063)
- Lei Zhang (ORCID: https://orcid.org/0000-0002-2227-0613)
- Yang Yu (ORCID: https://orcid.org/0000-0003-0252-293X)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Institute of Hematology & Blood Diseases Hospital (CN)
Publication Details
- Journal
- Haemophilia
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1111/hae.70066
- Primary Topic
- Hemophilia Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China