<scp>KIF2C</scp> Deletion Causes Meiotic Abnormalities and Nonobstructive Azoospermia in Mice
This study provides in vivo evidence that KIF2C is essential for spermatogenesis and male fertility in mice. The successful generation of global <i>Kif2c</i> KO mice establishes an animal model for NOA, supporting research on germ cell development and reproductive health.
Authors
- T. Imanaka (ORCID: https://orcid.org/0000-0002-5780-7564)
- Yuki Oyama (ORCID: https://orcid.org/0000-0001-5172-6600)
- Sohei Kuribayashi (ORCID: https://orcid.org/0000-0002-0564-6404)
- Shinichiro Fukuhara (ORCID: https://orcid.org/0000-0003-1336-4316)
- Kentaro Takezawa (ORCID: https://orcid.org/0000-0003-1137-1846)
- Hiroaki Kitakaze (ORCID: https://orcid.org/0009-0002-8421-7911)
- Yuma Kujime
- Haruhiko Miyata (ORCID: https://orcid.org/0000-0003-4758-5803)
- Masahito Ikawa (ORCID: https://orcid.org/0000-0001-9859-6217)
- Go Tsujimura (ORCID: https://orcid.org/0000-0003-4493-8917)
- Norio Nonomura (ORCID: https://orcid.org/0000-0002-6522-6233)
- Pan Chen (ORCID: https://orcid.org/0000-0001-8385-7760)
- Norichika Ueda
Institutions
- Osaka International Cancer Institute (JP)
- The University of Tokyo (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Reproductive Medicine and Biology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1002/rmb2.12659
- Primary Topic
- Microtubule and mitosis dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development
- Japan Society for the Promotion of Science
- Eunice Kennedy Shriver National Institute of Child Health and Human Development