Design, Synthesis and Evaluation of Novel Triphenyl Imidazole Derivatives Through In silico Studies

This study focuses on the design, synthesis and insilico analysis of novel Triphenyl imidazole derivatives.Debus-Radiziszewski imidazole synthesis is a simple and highly efficient method for synthesis of 2, 4, 5 -triphenyl imidazoles derivatives.Microwave assisted synthesis has emerged as a new lead in organic synthesis which makes the synthetic chemistry easy and effective.The structural integrity of the synthesized compounds was confirmed via comprehensive spectroscopic techniques, including Infrared Spectroscopy (IR).Molecular docking is studied to predict the binding affinity of ligands to receptor proteins.These findings not only validate the successful synthesis of the Triphenyl imidazole derivatives but also highlight their potential for further drug development.

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Publication Details

Journal
International Journal of Pharmaceutical Sciences Review and Research
Published
2025-04-01
DOI
https://doi.org/10.47583/ijpsrr.2025.v85i4.026
Primary Topic
Inorganic and Organometallic Chemistry
Type
article
Field-Weighted Citation Impact
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article

Design, Synthesis and Evaluation of Novel Triphenyl Imidazole Derivatives Through In silico Studies

M Anjana, H Abitha, V Gopika, Jaseera Rahmath K A et al.
International Journal of Pharmaceutical Sciences Review and Research
Inorganic and Organometallic Chemistry
article

Design, Synthesis and Evaluation of Novel Triphenyl Imidazole Derivatives Through In silico Studies

M Anjana, H Abitha, V Gopika, Jaseera Rahmath K A, ranjana Santhosh A
article en

Abstract

This study focuses on the design, synthesis and insilico analysis of novel Triphenyl imidazole derivatives.Debus-Radiziszewski imidazole synthesis is a simple and highly efficient method for synthesis of 2, 4, 5 -triphenyl imidazoles derivatives.Microwave assisted synthesis has emerged as a new lead in organic synthesis which makes the synthetic chemistry easy and effective.The structural integrity of the synthesized compounds was confirmed via comprehensive spectroscopic techniques, including Infrared Spectroscopy (IR).Molecular docking is studied to predict the binding affinity of ligands to receptor proteins.These findings not only validate the successful synthesis of the Triphenyl imidazole derivatives but also highlight their potential for further drug development.

International Journal of Pharmaceutical Sciences Review and ResearchVol. 85(4)
Openalex Percentile: Top 91%
Inorganic and Organometallic Chemistry
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