Comprehensive analysis of extensive drug-resistant <i>Salmonella</i> Typhi in Gujarat region, India: genomic findings and prospective alternative therapy

One of the first studies to assess the antimicrobial resistance patterns of <i>S</i>. Typhi isolates from the Ahmedabad and Vadodara regions; this particular investigation provides vital information on the occurrence of key resistance genes and mechanisms. This study has significantly contributed by finding the β-lactam/β-lactamase inhibitor combination therapy as an appropriate treatment choice for XDR, which can potentially use <i>S</i>. Typhi on a larger scale. Additionally, it provides the antibiotic resistance prediction of key antibiotics used for treating typhoidal fever. The outcomes of this investigation highlight the urgent need to address the surge of XDR <i>S</i>. Typhi in high-burden regions of Gujarat. Our study highlights the possibility of rapid dissemination of antibiotic resistance due to chromosomal point mutations and plasmid-mediated gene transfer. The effectiveness of β-lactam/β-lactamase inhibitors in handling XDR <i>S</i>. Typhi suggests a plausible strategy for treatment that may be included among clinical guidelines.