Natural History and Prognostic Factors of Chronic Urticaria in Children Aged < 2 Years: A Single‐Centered, Real‐World, and Retrospective Study

Background: To date, a limited number of studies have reported on the natural course and prognostic factors of chronic urticaria (CU) among children aged < 2 years. Objective: In this study, we delineated the characteristics and natural history of CU in children aged < 2 years, with an additional aim of identifying prognostic factors closely associated with CU. Methods: This study included children aged < 2 years who had CU between May 2019 and June 2023. The clinical data and laboratory results of these children were retrieved from their medical records or through telephone interviews. Results: The study population comprised 111 children with a median age of 16.30 (0.3–24) months at onset. Remission rates at 6, 12, and 36 months after the onset of CU were 36.08%, 51.55%, and 77.32%, respectively. After the sex and age at onset were adjusted, multivariate regression analysis revealed that allergic conjunctivitis was a risk factor for CU (OR adjusted = 5.14 [95% CI, 1.03–28.52]). Conclusion: The course of CU in children aged < 2 years is relatively short, with most children having a favorable outcome. Allergic conjunctivitis serves as a risk factor for CU in this age group.