<sup>129</sup> Xe-MRI ventilation and acinar abnormalities highlight the significance of spirometric dysanapsis: findings from the NOVELTY ADPro UK substudy
Participants with asthma and/or COPD, presenting to primary care with spirometric dysanapsis, exhibited increased lung abnormalities on <sup>129</sup>Xe-MRI, when compared with those with normal spirometry. Spirometric dysanapsis in asthma and/or COPD is therefore associated with significant lung disease, and the FEV1/FVC is related to the degree of airways abnormality on 129Xe-MRI.
Authors
- Jim M. Wild (ORCID: https://orcid.org/0000-0002-7246-8660)
- Laurie Smith (ORCID: https://orcid.org/0000-0002-5769-423X)
- Ho‐Fung Chan (ORCID: https://orcid.org/0000-0002-5382-2097)
- Smitha Rajaram (ORCID: https://orcid.org/0000-0001-5010-2353)
- Alberto Papi (ORCID: https://orcid.org/0000-0002-6924-4500)
- Andrew J. Swift (ORCID: https://orcid.org/0000-0002-8772-409X)
- James Ball (ORCID: https://orcid.org/0000-0003-4795-4007)
- Joshua Astley (ORCID: https://orcid.org/0000-0002-6552-5436)
- Guilhem Collier (ORCID: https://orcid.org/0000-0002-1874-4775)
- Nicholas Weatherley (ORCID: https://orcid.org/0000-0001-5589-2219)
- Bilal Tahir (ORCID: https://orcid.org/0000-0003-0531-3519)
- Graham Norquay (ORCID: https://orcid.org/0000-0002-4108-9035)
- Madhwesha Rao (ORCID: https://orcid.org/0000-0002-4109-4176)
- Leanne Armstrong
- Martin L Brook
- Jody Bray (ORCID: https://orcid.org/0000-0003-0700-5034)
- Paul Hughes (ORCID: https://orcid.org/0000-0002-7979-5840)
- Latife Hardaker
- Alberto Biancardi (ORCID: https://orcid.org/0009-0000-2765-0773)
- Helen Marshall (ORCID: https://orcid.org/0000-0002-7425-1449)
- David Capener (ORCID: https://orcid.org/0000-0003-2394-8729)
- Rod Hughes (ORCID: https://orcid.org/0009-0006-1200-5580)
- Demi Jakymelen
- Ryan Munro
- Oliver Rodgers
Institutions
- AstraZeneca (Netherlands) (NL)
- AstraZeneca (Singapore) (SG)
- The Priory Hospital (GB)
- St. Anna Hospital (DE)
- University of Sheffield (GB)
Publication Details
- Journal
- Thorax
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1136/thorax-2024-222347
- Citations
- 1
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- AstraZeneca
- National Institute for Health and Care Research
- Department of Health and Social Care
- Medical Research Council
- Engineering and Physical Sciences Research Council