Cadmium exposure, epigenetic modifications, and serum cystatin C: insights into mediated pathways and mortality risks in U.S. adults
We found higher blood cadmium is linked to increased serum cystatin C and DNAmCystatinC, with DNAmCystatinC partially mediating the effect on serum cystatin C. Notably, serum cystatin C may modify the relationship between cadmium exposure and mortality outcomes. Further research is warranted to elucidate these complex interactions.
Authors
- Ta‐Chen Su (ORCID: https://orcid.org/0000-0001-7523-7166)
- Chien‐Yu Lin (ORCID: https://orcid.org/0000-0002-6184-8852)
- Yu‐Wei Fang (ORCID: https://orcid.org/0000-0002-1302-1885)
- Ching‐Way Chen (ORCID: https://orcid.org/0000-0002-8516-4308)
Institutions
- Fu Jen Catholic University (TW)
- National Taiwan University (TW)
- National Taiwan University Hospital (TW)
- Memorial Hospital (US)
- National Yunlin University of Science and Technology (TW)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1186/s13148-025-01888-y
- Citations
- 2
- Primary Topic
- Heavy Metal Exposure and Toxicity
- Type
- article
- Field-Weighted Citation Impact
- 2.40
Funders
- Shin Kong Wu Ho-Su Memorial Hospital