Therapeutic Efficacy of Vernonia amygdalina and Persea americana Extracts in Mitigating Endothelial Dysfunction, Oxidative Stress, and Cardiac Biomarkers in Lipopolysaccharide-Induced Hypertension during Pregnancy

Objective: This study investigates the therapeutic efficacy of Vernonia amygdalina and Persea americana extracts in mitigating lipopolysaccharide-induced hypertension during pregnancy, focusing on endothelial dysfunction, oxidative stress, and cardiac biomarkers in albino rats. Materials and Methods: V. amygdalina and P. americana samples were collected, dried, powdered, and extracted using ethanol. Fifty-four pregnant Wistar rats were divided into nine groups, including a control group, an LPS-only group, and groups treated with various dosages of V. amygdalina and P. americana extracts. The effects on endothelial, oxidative stress, and cardiac biomarkers were assessed using standard methods. Results: The study demonstrated significant variations in TNF, GSH, GSSH, GPx, MDA, uric acid, and creatinine kinase levels among the treatment groups compared to the control. Conclusion: Vernonia amygdalina and Persea americana extracts demonstrated potential in mitigating lipopolysaccharide-induced hypertension during pregnancy, as evidenced by improvements in endothelial dysfunction, oxidative stress, and cardiac biomarkers in albino rats. The findings suggest the potential therapeutic use of V. amygdalina and P. americana in managing hypertensive disorders during pregnancy, highlighting their possible role as adjuncts or alternatives to conventional antihypertensive drugs.