Allele-specific vitamin D receptor binding is associated with pediatric-onset multiple sclerosis
This study is the first to use VDR-BVs from previous MR studies to demonstrate causal differences in VDR binding at a locus contributing to pedMS susceptibility.
Authors
- Timothy Edward Lotze (ORCID: https://orcid.org/0009-0003-2898-1963)
- Jan-Mendelt Tillema (ORCID: https://orcid.org/0000-0001-6933-8913)
- Defne Yilmaz (ORCID: https://orcid.org/0009-0009-0083-4797)
- Alice Rutatangwa (ORCID: https://orcid.org/0000-0003-0843-7947)
- Mark Gorman (ORCID: https://orcid.org/0000-0003-3694-8832)
- Mary Horton (ORCID: https://orcid.org/0000-0002-0854-4219)
- Amy Tara Waldman (ORCID: https://orcid.org/0000-0002-1054-0815)
- Leslie A. Benson (ORCID: https://orcid.org/0000-0002-1680-4834)
- Emmanuelle L. Waubant (ORCID: https://orcid.org/0000-0001-5188-0157)
- Jayne Ness (ORCID: https://orcid.org/0000-0001-8017-0138)
- Yolanda Wheeler (ORCID: https://orcid.org/0000-0003-1391-4496)
- Diana Quach (ORCID: https://orcid.org/0000-0001-5327-5436)
- Teri Schreiner (ORCID: https://orcid.org/0000-0002-3816-812X)
- Tanuja Chitnis (ORCID: https://orcid.org/0000-0002-9897-4422)
- Hong Quach (ORCID: https://orcid.org/0000-0003-0459-1971)
- Jennifer S. Graves (ORCID: https://orcid.org/0000-0003-1539-1940)
- Gregory Scott Aaen (ORCID: https://orcid.org/0000-0002-0408-2053)
- Soe Mar (ORCID: https://orcid.org/0000-0001-8449-2003)
- JOHN W. ROSE (ORCID: https://orcid.org/0000-0003-2382-5921)
- Cameron Adams (ORCID: https://orcid.org/0000-0003-2525-523X)
- Mary R. Rensel (ORCID: https://orcid.org/0000-0001-9613-8394)
- Bianca Weinstock‐Guttman (ORCID: https://orcid.org/0000-0001-6732-151X)
- Lisa F. Barcellos (ORCID: https://orcid.org/0000-0002-0303-3479)
- Theron Charles Casper (ORCID: https://orcid.org/0000-0001-7512-1294)
- Carla Francisco (ORCID: https://orcid.org/0000-0002-4628-3064)
Institutions
- Boston Children's Hospital (US)
- Cleveland Clinic (US)
- St. Louis Children's Hospital (US)
- Children's Hospital of Philadelphia (US)
- University of California, San Francisco (US)
- University of Utah (US)
- University of California System (US)
- Children's of Alabama (US)
- University of California San Diego (US)
- Massachusetts General Hospital (US)
- Mayo Clinic in Florida (US)
- Texas Children's Hospital (US)
- Jacobs Institute (US)
- Boston Children's Museum (US)
- Loma Linda University Children's Hospital (US)
- Mass General Brigham (US)
- University of Colorado Anschutz Medical Campus (US)
- University at Buffalo, State University of New York (US)
- University of Colorado Denver (US)
- University of California, Berkeley (US)
Publication Details
- Journal
- Multiple Sclerosis Journal - Experimental Translational and Clinical
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1177/20552173251335625
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Multiple Sclerosis Society
- National Institute of Allergy and Infectious Diseases
- National Institute of Neurological Disorders and Stroke
- National Institute of Environmental Health Sciences