Early Dynamics of Circulating Tumor HPV-DNA with Neoadjuvant Chemotherapy and Response-Adapted De-escalation in Human Papillomavirus–Associated Oropharyngeal Cancer
Rapid early clearance of ctHPV-DNA during neoadjuvant therapy demonstrates utility in predicting response to treatment. Detectable ctHPV-DNA following treatment is predictive of both disease recurrence and worse survival.
Authors
- Evgeny Izumchenko (ORCID: https://orcid.org/0000-0003-3500-5664)
- Noura J. Choudhury (ORCID: https://orcid.org/0000-0002-5980-4973)
- Alexander T. Pearson (ORCID: https://orcid.org/0000-0003-2801-7456)
- John Cursio (ORCID: https://orcid.org/0000-0003-2131-1767)
- Daniel J. Haraf (ORCID: https://orcid.org/0000-0001-5184-1166)
- Frederick S. Jones (ORCID: https://orcid.org/0000-0002-6534-8206)
- Nishant Agrawal (ORCID: https://orcid.org/0000-0002-1361-3231)
- Yuxuan Miao (ORCID: https://orcid.org/0000-0002-1534-7993)
- Ari J. Rosenberg (ORCID: https://orcid.org/0000-0001-5908-0939)
- Everett E. Vokes (ORCID: https://orcid.org/0000-0002-8645-8068)
- Augustin Vannier (ORCID: https://orcid.org/0000-0002-9467-0480)
- Emily L. Gramiccioni
- Zhen Gooi (ORCID: https://orcid.org/0000-0003-4325-6578)
- Rohan Katipally (ORCID: https://orcid.org/0000-0003-4587-5444)
- Anna Starus
- Rifat Hasina (ORCID: https://orcid.org/0000-0002-5800-5344)
- Jeffrey Chin
- Elizabeth A. Blair (ORCID: https://orcid.org/0000-0003-0614-1413)
- Aditya Juloori (ORCID: https://orcid.org/0000-0002-7486-6208)
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- Texas Medical Center (US)
- Chicago Department of Public Health (US)
- University of Illinois Chicago (US)
- University of Chicago (US)
- Sysmex (Japan) (JP)
- University of Baltimore (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-0152
- Citations
- 5
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 9.24
Funders
- U.S. Department of Defense
- American Cancer Society
- V Foundation for Cancer Research
- National Cancer Institute