Clinical Analysis of Pseudomonas aeruginosa Infections in Children Undergoing Chemotherapy or Hematopoietic Cell Transplantation: A Multicenter Nationwide Study

<b>Background</b>: <i>Pseudomonas aeruginosa</i> (PSA) infections are associated with a high recurrence rate and high mortality in immuno-compromised patients. There are limited studies regarding pediatric hematopoietic cell transplantation recipients. <b>Aim</b>: The nationwide multicenter study was conducted to analyze the epidemiology of PSA infections in children treated with chemotherapy (PHO, pediatric hematology and oncology) or undergoing hematopoietic allogeneic or autologous cell transplantation (HCT) in the period 2014-2023. <b>Methods</b>: We retrospectively analyzed the clinical and microbiological data of children who underwent anticancer therapy or hematopoietic cell transplantation in 17 Polish PHO centers and six pediatric HCT centers. The data were collected in two-year intervals. <b>Results</b>: During the 10-year study period, a total of 1629 HCTs (both autologous and allogeneic) and 9614 children newly diagnosed with neoplasms were analyzed. The cumulative incidence of PSA infection was similar in both groups (6.71% in PHO vs. 6.32% in HCT, <i>p</i> = 0.624). The total number of PSA bloodstream infections was comparable in the PHO and HCT groups (31.9% vs. 26.2%; <i>p</i> = 0.223). In both analyzed groups, the antipseudomonal drugs of choice were as follows: meropenem, ceftazidime, and tazobactam/piperaciline in combination with other antibiotics. In the HCT group, high rates of meropenem (20.4%) and tazobactam/piperaciline (18.4%) non-susceptibility were observed. This led to colistin therapy in 5.3% of patients. There was no difference in the median antibiotic therapy time in both groups; however, the survival rates from PSA infection were significantly lower in the HCT group (89.3% vs. 96.0%, <i>p</i> = 0.004). <b>Conclusions</b>: Although the risk of infection and the occurrence of resistant bacterial strains in HCT patients were comparable with those in PHO patients, the outcome of PSA infections was better in the PHO setting.

Authors

Institutions

Publication Details

Journal
Journal of Clinical Medicine
Published
2025-05-26
DOI
https://doi.org/10.3390/jcm14113714
Citations
1
Primary Topic
Antibiotic Resistance in Bacteria
Type
article
Field-Weighted Citation Impact
0.59
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Clinical Analysis of Pseudomonas aeruginosa Infections in Children Undergoing Chemotherapy or Hematopoietic Cell Transplantation: A Multicenter Nationwide Study

Agnieszka Urbanek‐Dądela, Patrycja Zalas‐Więcek, Zuzanna Gamrot, Filip Pierlejewski et al.
1 citations
Journal of Clinical Medicine
Antibiotic Resistance in Bacteria
0.59
article

Clinical Analysis of Pseudomonas aeruginosa Infections in Children Undergoing Chemotherapy or Hematopoietic Cell Transplantation: A Multicenter Nationwide Study

Agnieszka Urbanek‐Dądela, Patrycja Zalas‐Więcek, Zuzanna Gamrot, Filip Pierlejewski, Łukasz Hutnik, Renata Tomaszewska, Weronika Stolpa, Małgorzata Salamonowicz, Iwona Żak, Agnieszka Gietka, Jolanta Goździk, Olga Gryniewicz–Kwiatkowska, Anna Szmydki‐Baran, Marcin Płonowski, Katarzyna Semczuk, Jowita Frączkiewicz, Olga Zając‐Spychała, Zofia Małas, Ninela Irga‐Jaworska, Wanda Badowska, Ewa Bień, Liliana Chełmecka, Agnieszka Zaucha‐Prażmo, Jan Styczyński, Paweł Wawryków, Monika Richert-Przygońska, Magdalena Bartnik, Jakub Musiał, Krzysztof Czyżewski
article en
1 citations

Abstract

<b>Background</b>: <i>Pseudomonas aeruginosa</i> (PSA) infections are associated with a high recurrence rate and high mortality in immuno-compromised patients. There are limited studies regarding pediatric hematopoietic cell transplantation recipients. <b>Aim</b>: The nationwide multicenter study was conducted to analyze the epidemiology of PSA infections in children treated with chemotherapy (PHO, pediatric hematology and oncology) or undergoing hematopoietic allogeneic or autologous cell transplantation (HCT) in the period 2014-2023. <b>Methods</b>: We retrospectively analyzed the clinical and microbiological data of children who underwent anticancer therapy or hematopoietic cell transplantation in 17 Polish PHO centers and six pediatric HCT centers. The data were collected in two-year intervals. <b>Results</b>: During the 10-year study period, a total of 1629 HCTs (both autologous and allogeneic) and 9614 children newly diagnosed with neoplasms were analyzed. The cumulative incidence of PSA infection was similar in both groups (6.71% in PHO vs. 6.32% in HCT, <i>p</i> = 0.624). The total number of PSA bloodstream infections was comparable in the PHO and HCT groups (31.9% vs. 26.2%; <i>p</i> = 0.223). In both analyzed groups, the antipseudomonal drugs of choice were as follows: meropenem, ceftazidime, and tazobactam/piperaciline in combination with other antibiotics. In the HCT group, high rates of meropenem (20.4%) and tazobactam/piperaciline (18.4%) non-susceptibility were observed. This led to colistin therapy in 5.3% of patients. There was no difference in the median antibiotic therapy time in both groups; however, the survival rates from PSA infection were significantly lower in the HCT group (89.3% vs. 96.0%, <i>p</i> = 0.004). <b>Conclusions</b>: Although the risk of infection and the occurrence of resistant bacterial strains in HCT patients were comparable with those in PHO patients, the outcome of PSA infections was better in the PHO setting.

Journal of Clinical MedicineVol. 14(11)
Poznan University of Medical Sciences (PL), Medical University of Lublin (PL), Jagiellonian University (PL), Medical University of Białystok (PL), Medical University of Silesia (PL), Kielce University of Technology (PL), Medical University of Warsaw (PL), Nicolaus Copernicus University (PL), Wroclaw Medical University (PL), Uniwersytecki Szpital Dziecięcy (PL), Children's Memorial Health Institute (PL), University of Computer Sciences and Economics in Olsztyn (PL), Medical University of Lodz (PL), Gdańsk Medical University (PL), Pomeranian Medical University (PL), University of Rzeszów (PL)
Good health and well-being
Openalex Percentile: Top 35%
Antibiotic Resistance in Bacteria
0.59
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.