Identification and Targeting of <i>POLQ</i> -Associated Hereditary Colorectal Cancer
This study identifies POLQ as a pathogenic gene in hereditary colorectal cancer, unveiling a novel POLQ-type colorectal cancer driven by TMEJ hyperactivation. Screening for POLQ mutations in patients with hereditary adenomas or early-onset colorectal cancer would benefit early diagnosis and personalized therapy for POLQ-associated colorectal cancer; however, further clinical validation is warranted.
Authors
- Bei-Bei Gan
- Ning Xu (ORCID: https://orcid.org/0000-0002-7770-8731)
- Feng-Chang Huang
- Yu Fan (ORCID: https://orcid.org/0000-0002-5978-5004)
- Mao-Sen Ye
- Min Xu
- Wenhui Li (ORCID: https://orcid.org/0000-0002-0312-7993)
- Dengfeng Zhang (ORCID: https://orcid.org/0000-0002-0777-5859)
- Yu Li (ORCID: https://orcid.org/0000-0002-6359-9626)
- Wen-Liang Li (ORCID: https://orcid.org/0000-0003-0928-337X)
- Xiao-Xiao Shi
- Ke-Xin Yang
- Yong‐Gang Yao (ORCID: https://orcid.org/0000-0002-2955-0693)
- Jianlin Ren (ORCID: https://orcid.org/0000-0002-4973-7076)
- Rui Bi (ORCID: https://orcid.org/0000-0003-1779-7450)
- Yong-Chun Zhou
Institutions
- Kunming Institute of Zoology (CN)
- Chinese Academy of Sciences (CN)
- Kunming Medical University (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
- Yan'an Hospital Affiliated To Kunming Medical University (CN)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-0379
- Citations
- 1
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- National Natural Science Foundation of China
- Applied Basic Research Foundation of Yunnan Province
- Major Science and Technology Projects in Yunnan Province