Ligustrazine nano-drug delivery system ameliorates doxorubicin-mediated myocardial injury via piezo-type mechanosensitive ion channel component 1-prohibitin 2-mediated mitochondrial quality surveillance
The PHB2Ser91/Ser176 phosphorylation axis regulated by PIEZO1-TMBIM6 is an important target for LIG nano-drug delivery systems to improve mitochondrial damage in DIC.
Authors
- Hongshuo Shi (ORCID: https://orcid.org/0000-0003-0012-5869)
- Sang‐Bing Ong (ORCID: https://orcid.org/0000-0001-7421-2610)
- Ruiqi Cai (ORCID: https://orcid.org/0000-0003-2428-0759)
- Boxian Pang (ORCID: https://orcid.org/0000-0002-3400-6879)
- Yingzhen Du (ORCID: https://orcid.org/0000-0003-3352-8824)
- Chun Li (ORCID: https://orcid.org/0000-0002-2376-4703)
- Hao Zhou (ORCID: https://orcid.org/0000-0002-2901-3804)
- Xing Chang
- Zhijiang Guo (ORCID: https://orcid.org/0009-0003-5653-8440)
- Haowen Zhuang (ORCID: https://orcid.org/0009-0002-2484-4235)
- Yifeng Nie
- Junyan Wang
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Chinese University of Hong Kong (HK)
- Liaoning University of Traditional Chinese Medicine (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- National Center for Nanoscience and Technology (CN)
- Shuguang Hospital (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1186/s12951-025-03420-z
- Citations
- 58
- Primary Topic
- Ion channel regulation and function
- Type
- article
- Field-Weighted Citation Impact
- 46.75