Blood Concentrations of Osimertinib and Its Active Metabolites: Impact on Treatment Efficacy and Safety
Higher OSI blood concentrations were associated with a longer PFS, while higher blood concentrations of AZ5104 and AZ7550 were observed in patients with higher hematological toxicity grades. Further research is needed to determine the optimal blood levels of OSI that improve prognosis and minimize toxicity.
Authors
- Takeshi Isobe (ORCID: https://orcid.org/0000-0002-3498-9772)
- Masafumi Hongoh
- Takae Okuno (ORCID: https://orcid.org/0000-0002-2841-2547)
- Tamio Okimoto (ORCID: https://orcid.org/0000-0001-8295-1296)
- Yukari Tsubata (ORCID: https://orcid.org/0000-0002-4260-2849)
- Ryosuke Tanino (ORCID: https://orcid.org/0000-0002-5148-9526)
Institutions
- Shimane University (JP)
- Shimane University Hospital (JP)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-05-27
- DOI
- https://doi.org/10.21873/anticanres.17627
- Citations
- 1
- Primary Topic
- Chronic Myeloid Leukemia Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.77