Phase II Study of the Effectiveness of the Germinated Wheat-derived Rigenase Plus Polyhexanide in the Prophylaxis for Hypofractionated Radiation-induced Acute Skin Toxicity in Breast Cancer
Patients treated with adjuvant hypo-fractionated radiotherapy for breast cancer developed grade 2 RIST in slightly less than a quarter of cases with the use of rigenase/polyhexanide. No treatment delays or withdrawals were observed because of RIST. The tolerance was excellent.
Authors
- Santa Bambace
- Ivan Fazio
- Vincenzo Iorio (ORCID: https://orcid.org/0000-0002-0249-5997)
- Maria Rosaria Valerio (ORCID: https://orcid.org/0000-0003-3589-4684)
- Grazia Lazzari (ORCID: https://orcid.org/0000-0002-9137-2007)
- Paolo Muto (ORCID: https://orcid.org/0000-0002-7546-6441)
- Francesca Doria
- Giuseppa Scandurra (ORCID: https://orcid.org/0000-0001-8025-581X)
- M. Enfasi
- Sarah Parisi
- Antonino Daidone
- M. Boccardi
- Daniela Sambataro (ORCID: https://orcid.org/0009-0008-3909-9833)
- Nicola Rosa (ORCID: https://orcid.org/0000-0002-2366-6556)
- Antonella Fanelli (ORCID: https://orcid.org/0000-0002-7561-5486)
- Andrea Girlando
- Giuseppe Iatì (ORCID: https://orcid.org/0000-0001-6287-2806)
- ANNALISA LA MACCHIA
- Alfio Di Grazia
- V. Carfora
- Cesare Guida (ORCID: https://orcid.org/0000-0003-3687-2006)
- Angela Solazzo (ORCID: https://orcid.org/0000-0002-2522-468X)
- Gianluca Mortellaro
- Vincenzo Barone (ORCID: https://orcid.org/0000-0001-6420-4107)
- Vittorio Gebbia (ORCID: https://orcid.org/0000-0001-8406-9416)
- Pietro Delia
- Salvatore Bonanno
- M. Muto
- A. Pepe
- Antonio Spera
Institutions
- Ospedali Riuniti di Foggia (IT)
- Ospedale Cannizzaro (IT)
- Ospedale D. Cotugno (IT)
- Ospedali Riuniti Umberto I (IT)
- University of Palermo (IT)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-05-27
- DOI
- https://doi.org/10.21873/anticanres.17626
- Primary Topic
- Nonmelanoma Skin Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00