The Role of EMP2 in Triple-negative Breast Cancer
Del-1 and EMP2 are over-expressed in TNBC and show an inverse regulatory relationship. Del-1 knockdown promotes stemness features, while EMP2 knockdown reduces proliferation and increases chemosensitivity. These findings highlight the Del-1/EMP2 axis as a potential regulatory pathway in TNBC progression and resistance, suggesting that EMP2 may serve as a novel therapeutic target.
Authors
- E. Kim
- Jin Hyang Jung
- Ho Yong Park (ORCID: https://orcid.org/0000-0002-4380-0089)
- Byeongju Kang (ORCID: https://orcid.org/0000-0002-3589-5559)
- Soo Jung Lee (ORCID: https://orcid.org/0000-0003-0066-4109)
- Ji Young Park (ORCID: https://orcid.org/0000-0002-1857-813X)
- Ji Young Park (ORCID: https://orcid.org/0000-0002-7571-1064)
- Jeeyeon Lee (ORCID: https://orcid.org/0000-0003-1826-1690)
- Jieun Kang
- In Hee Lee (ORCID: https://orcid.org/0000-0002-0139-9768)
- Yee Soo Chae
Institutions
- Kyungpook National University Hospital (KR)
- Kyungpook National University (KR)
Publication Details
- Journal
- Anticancer Research
- Published
- 2025-05-27
- DOI
- https://doi.org/10.21873/anticanres.17613
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81