Synthesis and Nucleophilic Ring-Opening of 1,1-Dicyanocyclopropanes: Accessing β-Aminocarbonyl Derivatives from Olefins
We report an atom-transfer radical addition-ring closure sequence for the preparation of 1,1-dicyanocyclopropane electrophiles and demonstrate their nucleophilic ring-opening with alkyl amines under mild conditions. The resulting aminomalononitrile products were converted to complex β-aminocarbonyl derivatives in one pot under aerobic conditions.
Authors
- Adrián Gómez‐Suárez (ORCID: https://orcid.org/0000-0003-4822-6554)
- Stefan F. Kirsch (ORCID: https://orcid.org/0000-0003-2628-8703)
- Sebastian Govaerts (ORCID: https://orcid.org/0000-0002-0742-9243)
- Jan Lukas Mayer-Figge
- Mohit Chotia
Institutions
- University of Wuppertal (DE)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1021/acs.orglett.5c00395
- Citations
- 2
- Primary Topic
- Cyclopropane Reaction Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Deutsche Forschungsgemeinschaft