A General Deoxygenative Hydrosilylation of Oxo Chemicals Catalyzed by a Bipyridine-Ligated Chromium Complex
We report the general deoxygenative hydrosilylation of oxo chemicals that was catalyzed by an air-stable bipyridine-ligated chromium complex. A broad range of oxygen-containing compounds such as carboxylic esters, ketones, aldehydes, alcohols, and ethylene oxides can be used as precursors, providing a versatile strategy for the formation of methyl- or methylene-bearing motifs by the dissipation of oxygen moieties. The method has been applied to the synthesis of several bioactive molecules.
Authors
- Xiaoming Zeng (ORCID: https://orcid.org/0000-0003-0509-1848)
- Meiming Luo (ORCID: https://orcid.org/0000-0003-1766-9010)
- Rui Wei (ORCID: https://orcid.org/0000-0002-6984-5699)
- Liang Ling
- Shu-Jiang Tu (ORCID: https://orcid.org/0009-0007-5501-8784)
Institutions
- Sichuan University (CN)
- Green Chemistry (PL)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1021/acs.orglett.5c01466
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities