Bidirectional causal relationship between obesity and osteoarthritis: Insights from a two-sample Mendelian randomization study
This study provides strong evidence supporting a causal effect of obesity (measured by BMI) on OA, with a more pronounced effect in weight-bearing knee & hip joints compared to non-weight-bearing hand joint. There was no causal evidence for the reverse direction. Future research could look more in depth into differences in the genetic variants that may represent different biological underlying mechanisms.
Authors
- Sita Bierma‐Zeinstra (ORCID: https://orcid.org/0000-0003-1280-5896)
- William Thompson (ORCID: https://orcid.org/0000-0003-0106-8309)
- Weiya Zhang (ORCID: https://orcid.org/0000-0003-1142-1460)
- Joyce B. J. van Meurs (ORCID: https://orcid.org/0000-0001-6245-2123)
- J. Runhaar (ORCID: https://orcid.org/0000-0002-6293-6707)
- Katerina Trajanoska (ORCID: https://orcid.org/0000-0002-3792-4296)
- Anne Kamps (ORCID: https://orcid.org/0000-0002-8998-6501)
- Bahareh Sedaghati-khayat (ORCID: https://orcid.org/0000-0002-7665-8648)
Institutions
- University of Nottingham (GB)
- Erasmus MC (NL)
- McGill University (CA)
Publication Details
- Journal
- Osteoarthritis and Cartilage Open
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1016/j.ocarto.2025.100636
- Citations
- 2
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 3.63