Imidazolyl ethanamide pentandioic acid promotes hematopoietic recovery following sublethal radiation in a murine model
Our results reveal that IEPA attenuated radiation-induced DNA damage and improved recovery of HSCs/HPCs, myeloid as well as lymphoid progenitors, accompanied by increases in platelets in blood, megakaryocytes in BM and splenic CD34<sup>+</sup> cells. IEPA shows promise as a radiation mitigator, with no significant benefit observed from adding GM-CSF.
Authors
- Dirk Pleimes (ORCID: https://orcid.org/0000-0002-0876-9418)
- Srishti Munjal Mehta (ORCID: https://orcid.org/0000-0002-7834-5848)
- Corinna Asang (ORCID: https://orcid.org/0009-0003-4454-2098)
- Basveshwar Gawali (ORCID: https://orcid.org/0000-0002-2086-6325)
- Snehalata A. Pawar (ORCID: https://orcid.org/0000-0003-3992-2494)
- Suresh Veeraperumal (ORCID: https://orcid.org/0000-0002-4021-595X)
- Maciej T. Czajkowski (ORCID: https://orcid.org/0000-0002-1161-1187)
- Narsingh B. Singh (ORCID: https://orcid.org/0000-0002-5015-1996)
- Seren Sevim-Wunderlich (ORCID: https://orcid.org/0009-0008-2771-4149)
Institutions
- SUNY Upstate Medical University (US)
- Myelo Therapeutics (Germany) (DE)
Publication Details
- Journal
- International Journal of Radiation Biology
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1080/09553002.2025.2505526
- Primary Topic
- Effects of Radiation Exposure
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of Allergy and Infectious Diseases