Neuropsychological and clinical variables associated with cognitive trajectories in patients with Alzheimer's disease
This is the first AI study to predict cognitive trajectories of AD patients using routinely collected clinical data, while at the same time providing explainability of factors contributing to these trajectories. Also, our study used the results of single cognitive tests as a measure of specific cognitive functions allowing for a finer-grained analysis of risk factors with respect to the other studies that have principally used aggregated scores obtained by short neuropsychological batteries. The outcomes of this work can aid prognostic interpretation of the clinical and cognitive variables associated with the initial phase of the disease towards personalized therapies.
Authors
- Venet Osmani (ORCID: https://orcid.org/0000-0001-7306-2972)
- Marianna Riello (ORCID: https://orcid.org/0000-0001-6889-9241)
- Sara Garbarino (ORCID: https://orcid.org/0000-0002-3583-3630)
- Bruno Giometto (ORCID: https://orcid.org/0000-0003-2311-9752)
- Antonio Uccelli (ORCID: https://orcid.org/0000-0002-2008-6038)
- Monica Moroni (ORCID: https://orcid.org/0000-0003-1852-7217)
- Raffaella Di Giacopo (ORCID: https://orcid.org/0009-0009-7652-0006)
- Stefano Bovo (ORCID: https://orcid.org/0000-0002-0278-6786)
- Lorenzo Gios (ORCID: https://orcid.org/0000-0003-2981-0851)
- Manuela Buganza
- Flavio Ragni (ORCID: https://orcid.org/0000-0001-7767-7288)
- Federico Massa (ORCID: https://orcid.org/0000-0001-5667-204X)
- Marco Chierici (ORCID: https://orcid.org/0000-0001-9791-9301)
- Matteo Pardini (ORCID: https://orcid.org/0000-0002-4740-1982)
- Cristina Campi (ORCID: https://orcid.org/0000-0003-2105-8554)
- Manuela Marenco (ORCID: https://orcid.org/0000-0003-4328-8000)
- Monica Dallabona
- Michele Piana (ORCID: https://orcid.org/0000-0003-1700-991X)
- Giuseppe Jurman (ORCID: https://orcid.org/0000-0002-2705-5728)
- Elisa Vanzetta
Institutions
- University of Trento (IT)
- Fondazione Bruno Kessler (IT)
- Provincia Autonoma di Trento (IT)
- Ospedale Policlinico San Martino (IT)
- Trentino Network (Italy) (IT)
- University of Genoa (IT)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-05-27
- DOI
- https://doi.org/10.3389/fnagi.2025.1565006
- Citations
- 1
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 1.47