Dose-dependent immunotoxic mechanisms of celastrol via modulation of the PI3K-Akt signaling pathway
Our study demonstrates the dose-dependent immunotoxic effects of celastrol, which is toxic in high doses caused by activation of the PI3K-Akt signaling pathway, while low doses offer protection by blocking this signaling pathway. These findings emphasize the importance of dose selection in therapeutic and safety contexts, enhancing understanding of celastrol's biological effects and its clinical potential in immune-related diseases.
Authors
- Jingyuan Fu (ORCID: https://orcid.org/0000-0001-5578-1236)
- Chunli Shen
- Jin‐Kun Wen (ORCID: https://orcid.org/0000-0002-8453-4549)
- Shaohui Geng (ORCID: https://orcid.org/0000-0002-7941-4753)
- Guangrui Huang (ORCID: https://orcid.org/0000-0003-1846-0227)
- Zi Ye (ORCID: https://orcid.org/0000-0001-8660-3037)
- Liu L (ORCID: https://orcid.org/0000-0001-9234-457X)
- Chen Li (ORCID: https://orcid.org/0009-0000-0090-0277)
- Yu Jiang (ORCID: https://orcid.org/0000-0002-7501-8294)
- Yuanhao Wu (ORCID: https://orcid.org/0000-0002-3955-6474)
- Yiwei Guan
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
- Beijing University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-05-27
- DOI
- https://doi.org/10.3389/fphar.2025.1567193
- Citations
- 9
- Primary Topic
- Natural Compounds in Disease Treatment
- Type
- article
- Field-Weighted Citation Impact
- 21.43
Funders
- National Natural Science Foundation of China
- Beijing University of Chinese Medicine
- Foundation for Innovative Research Groups of the National Natural Science Foundation of China