Catering to the Era of Gene Therapy: An Objective Staging Strategy for Bietti Crystalline Dystrophy using Principal Component Regression
We developed an innovative and objective scoring and staging strategy for BCD by integrating 6 variables and utilizing the PCR approach. This strategy advances BCD assessment and serves as a benchmark for the natural history evaluation and staging of other IRDs.
Authors
- Huixun Jia (ORCID: https://orcid.org/0000-0001-9341-5587)
- Jieqiong Chen
- Chenyue Hang (ORCID: https://orcid.org/0000-0003-2311-7255)
- Tianyuan Zhao
- Yuanyuan Gong (ORCID: https://orcid.org/0000-0002-1266-3915)
- Xiaoling Wan (ORCID: https://orcid.org/0000-0003-4583-8686)
- Tong Li (ORCID: https://orcid.org/0000-0002-2544-1254)
- Ting Zhang (ORCID: https://orcid.org/0000-0001-5967-0525)
- Xiaodong Sun (ORCID: https://orcid.org/0000-0002-9451-3311)
- Suqin Yu
- Junran Sun (ORCID: https://orcid.org/0000-0001-6545-5223)
- Zhixuan Chen (ORCID: https://orcid.org/0000-0001-8767-7177)
Institutions
- Shanghai Eye Disease Prevention & Treatment Center (CN)
- Shanghai First People's Hospital (CN)
- Shanghai Clinical Research Center (CN)
Publication Details
- Journal
- American Journal of Ophthalmology
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1016/j.ajo.2025.05.018
- Primary Topic
- RNA regulation and disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Shanghai Municipal Education Commission
- Science and Technology Commission of Shanghai Municipality