Randomised Comparison of Culotte- versus Double Kissing Crush Stenting in de novo non-left Main Coronary Bifurcation Lesions: Rationale and Design of the Bifurcation Bad Krozingen trial-3 (BBK-3)
Whether culotte or double kissing (DK)-crush stenting is the superior systematic 2-stent technique in non-left main bifurcation lesions is unclear. The BBK-3 (unique identifier NCT04192760) is a multicenter, prospective, randomized controlled trial to test the hypothesis that culotte stenting reduces maximal percent diameter restenosis at 9-month follow-up compared to DK-crush stenting in de-novo non-left main coronary bifurcation lesions using approved, third-generation drug-eluting stents (DES). A total of 400 patients will be randomized in a 1:1 ratio to receive a two-stent strategy. The primary study endpoint is the maximal percent diameter in-stent restenosis within the bifurcation at 9 months, assessed by quantitative coronary angiography. Secondary endpoints include target lesion revascularization (TLR), the composite of death and myocardial infarction, emergent cardiac bypass surgery and TLR (MACE) at 12 months. BBK-3 will assist in the identification of the preferable, contemporary 2-stent strategy in the treatment of de-novo non-left main coronary bifurcation lesions.
Authors
- Franz‐Josef Neumann (ORCID: https://orcid.org/0000-0002-9478-2757)
- Adnan Kastrati (ORCID: https://orcid.org/0000-0003-4341-891X)
- Samuel Tobias Sossalla (ORCID: https://orcid.org/0000-0001-8034-2673)
- Philipp Breitbart (ORCID: https://orcid.org/0000-0002-7390-5287)
- Kilian Franke
- Mohamed Abdel‐Wahab (ORCID: https://orcid.org/0000-0002-9596-558X)
- Tau Hartikainen (ORCID: https://orcid.org/0000-0003-0966-7250)
- Constantin von zur Mühlen (ORCID: https://orcid.org/0000-0003-2767-8009)
- Christoph B. Olivier (ORCID: https://orcid.org/0000-0002-3065-625X)
- Christian Valina (ORCID: https://orcid.org/0000-0003-3900-3500)
- Nikolaus Löffelhardt
- Jan Minners
- Mirosław Ferenc (ORCID: https://orcid.org/0000-0002-1006-5014)
- Faridun Rahimi
- Albrecht Elsaesser
- Dirk Westermann
- Felix Woitek
- Thomas Nührenberg
- Willibald Hochholzer
Institutions
- Universitätsklinikum Gießen und Marburg (DE)
- University Medical Center Freiburg (DE)
- Klinikum Oldenburg (DE)
- Leipzig Heart Institute (DE)
- Universitäts-Herzzentrum Freiburg-Bad Krozingen (DE)
- Kerckhoff Klinik (DE)
- Klinikum Würzburg Mitte (DE)
- Deutsches Herzzentrum München (DE)
- Technische Universität Dresden (DE)
- Leipzig University (DE)
Publication Details
- Journal
- Journal of Cardiovascular Translational Research
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1007/s12265-025-10626-x
- Citations
- 3
- Primary Topic
- Coronary Interventions and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 6.02
Funders
- Boston Scientific Corporation