Resveratrol mitigates activated astrocytes and microglia preventing Alzheimer’s Disease (AD) progression and facilitates neuronal communication in Amyloid-β25–35 induced rat model for AD: A special emphasis on non-neuronal involvement in AD pathophys
These findings suggest that RSV effectively reduces neuroinflammation, promotes neurogenesis in the sub granular zone of the hippocampus, and improves learning and memory in both control and AD conditions via SIRT1. This study highlights RSV's potential as a suitable therapeutic agent for AD.
Authors
- Kumar Surya
- Mahesh Kandasamy (ORCID: https://orcid.org/0000-0002-6720-9082)
- Kesavan Swaminathan Jayachandran
- Muthuswamy Anusuyadevi (ORCID: https://orcid.org/0000-0003-0576-1776)
- Meher Nisha Abubakkar
- Anitha Rathinam
Institutions
- University Grants Commission (IN)
- Bharathidasan University (IN)
Publication Details
- Journal
- Psychopharmacology
- Published
- 2025-05-26
- DOI
- https://doi.org/10.1007/s00213-025-06814-x
- Citations
- 5
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 4.21
Funders
- Tamilnadu State Council For Science And Technology
- Department of Science and Technology, Ministry of Science and Technology, India
- Indian Council of Medical Research
- Rashtriya Uchchatar Shiksha Abhiyan