Mesenchymal stem cells reduce the genotoxic effect of lead acetate in the testis of male rats and induce testicular cellular proliferation indicated by 16S rRNA sequence, increase the proliferation marker Ki-67 and a reduction in the apoptosis marker
It can be concluded that the MSCs are a potential therapeutic for the treatment of testicular dysfunction induced by LA through the reduction of oxidative stress, genotoxic effect, and apoptosis marker caspase-3, and an increase in the proliferation marker Ki-67 in the testicular tissue associated with restoration of hormonal imbalance.
Authors
- Samer S. Fouad (ORCID: https://orcid.org/0000-0003-1356-1539)
- Mariam A. Fawy
- Yahia A. Amin (ORCID: https://orcid.org/0000-0003-4075-2664)
- Mohamed Farouk Allam (ORCID: https://orcid.org/0000-0001-5954-8909)
- Rana Toghan (ORCID: https://orcid.org/0000-0002-7254-6104)
- Maha Abd-El Baki Ahmed
- Rana A. Ali
- LAILA ALI
Institutions
- South Valley University (EG)
- Aswan University (EG)
Publication Details
- Journal
- Biological Research
- Published
- 2025-05-27
- DOI
- https://doi.org/10.1186/s40659-025-00614-5
- Citations
- 6
- Primary Topic
- Heavy Metal Exposure and Toxicity
- Type
- article
- Field-Weighted Citation Impact
- 7.20
Funders
- Science and Technology Development Fund
- Aswan University